β–caryophyllene is commonly found in a lot of plants such has Thai basils, cloves, cinnamon leaves and black pepper, and in minor quantities in lavender. Caryophyllene is usually mix with spicy mixtures or citrus flavorings. Chewing gum is especially used with Caryophyllene.
Studies show β–caryophyllene holds promise in cancer treatment plans. Just to name a few that threat that nasty disease. β–caryophyllene selectively binds to the CB2 receptor and that it is a functional CB2 agonist. Further, β–caryophyllene was identified as a functional non-psychoactive CB2 receptor ligand in foodstuff and as a macrocyclic anti-inflammatory cannabinoid in cannabis.
The Fine/Rosenfeld pain study demonstrates that other phytocannabinoids in combination, especially cannabidiol (CBD) and β-caryophyllene, delivered by the oral route appear to be promising candidates for the treatment of chronic pain due to their high safety and low adverse effects profiles.
The Jeena, Liju et al study investigated the chemical composition of essential oil isolated from black pepper, of which caryophyllene is a main constituent, and studied its pharmacological properties. Black pepper oil was found to possess antioxidant, anti-inflammatory and antinociceptive properties. This suggests that high-caryophyllene strains may be useful in treating a number of medical issues such as arthritis and neuropathy pain.